منابع مشابه
Epigenetic gene silencing underlies C-fiber dysfunctions in neuropathic pain.
Peripheral nerve injury causes neuropathic pain, which is characterized by the paradoxical sensations of positive and negative symptoms. Clinically, negative signs are frequently observed; however, their underlying molecular mechanisms are largely unknown. Dysfunction of C-fibers is assumed to underlie negative symptoms and is accompanied by long-lasting downregulation of Na(v)1.8 sodium channe...
متن کاملACUPUNCTURE AND NEUROPATHIC PAIN About neuropathic pain
Neuropathic pain results from damage to, or dysfunction of, the system that normally signals pain. The International Association for the Study of Pain (IASP 2007) defines neuropathic pain as follows: ‘Pain initiated or caused by a primary lesion or dysfunction in the nervous system. Peripheral neuropathic pain occurs when the lesion or dysfunction affects the peripheral nervous system. Central ...
متن کاملNeuropathic pain
Neuropathic pain (NP) is defined as ''pain arising as a direct consequence of any lesion or disease affecting the somatosensory system. " [1,2] Although NP may be an idiopathic process reflecting abnormal sensory processing in the peripheral or central nervous system, it more often appears following physical insult or disease affecting the peripheral or central nervous system. It is likely that...
متن کاملNeuropathic Pain
What is Neuropathic Pain? A limited understanding of underlying pathophysiology, and recent changes in terminology have led to some confusion. The International Association for the Study of Pain (IASP) defines NP as "pains resulting from disease or damage of the peripheral or central nervous systems, and from dysfunction of the nervous system". Originally, NP was used to describe only pain rela...
متن کاملNeuropathic pain.
Neuropathic pain refers to pain that originates from pathology of the nervous system. Common causes of neuropathic pain are diabetes mellitus, reactivation of herpes zoster, nerve compression or radiculopathy, alcohol, chemotherapy or abuse of some drugs, and trigeminal neuralgia. Specific symptoms of neuropathic pain are mechanical allodynia and cold hyperalgesia. Drugs to treat neuropathic pa...
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ژورنال
عنوان ژورنال: Science-Business eXchange
سال: 2013
ISSN: 1945-3477
DOI: 10.1038/scibx.2013.711